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CS-W001157 4
Total: USD 88.00

4-Bromo-7-methoxy-1H-indazole

  • CAS No. 938062-01-2

  • Cat. No. CS-0039167
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-7-methoxy-1H-indazole|CS-0039167

Structure of 938062-01-2

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General Information

  • CAS No. 938062-01-2
  • Cat. No. CS-0039167
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrN₂O
  • Molecular Weight 227.06
  • Synonym(s) None
  • SMILES COC1=CC=C(C2=CNN=C21)Br

Description

4-Bromo-7-methoxy-1H-indazole is a heterocyclic building block featuring a bromine atom at the 4-position and a methoxy group at the 7-position, enabling diverse downstream functionalization. This electron-deficient indazole scaffold integrates readily into medicinal chemistry campaigns, offering enhanced metabolic stability and tunable solubility for target-specific compound libraries.

Application

4-Bromo-7-methoxy-1H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo substituent. The methoxy group enhances solubility and modulates electronic properties, while the indazole core provides a bioisosteric scaffold for nitrogen-rich heterocycles. Its bench-stable nature and compatibility with standard synthetic protocols facilitate efficient incorporation into complex molecules.

Synthesis

  • Route1
    • 3-Bromo-6-methoxy-2-methylaniline|CS-0672038
      786596-55-2
    • ~86%
    • In-stock
      4-Bromo-7-methoxy-1H-indazole|CS-0039167
      938062-01-2

    References

    • WYETH Patent: WO2009/111260 A1, 2009 ; Location in patent: Page/Page column 36 ; WO 2009/111260 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.91
  • LogP   2.334
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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