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CS-W001157 4
Total: USD 88.00

2-Amino-2-(4-hydroxyphenyl)acetic acid

  • CAS No. 938-97-6

  • Cat. No. CS-W005226
  • Purity≥98%
  • MDL No.MFCD00065931

*For research and further manufacturing use only, not for direct human use.

2-Amino-2-(4-hydroxyphenyl)acetic acid|CS-W005226

Structure of 938-97-6

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General Information

  • CAS No. 938-97-6
  • Cat. No. CS-W005226
  • Purity ≥98%
  • MDL No. MFCD00065931
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₃
  • Molecular Weight None
  • Synonym(s) p-Hydroxyphenylglycine
  • SMILES NC(C(O)=O)C1=CC=C(O)C=C1

Description

2-Amino-2-(4-hydroxyphenyl)acetic acid features a phenolic hydroxyl group flanked by an amino-substituted acetic acid backbone, enabling integration into bioconjugation workflows and peptide synthesis. This bench-stable scaffold offers enhanced solubility in aqueous media and serves as a key building block for functionalized molecular probes and pharmaceutical intermediates.

Application

2-Amino-2-(4-hydroxyphenyl)acetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of phenolic β-amino acids and related scaffolds. Its dual functionality—amine and phenolic hydroxyl—supports diverse derivatization pathways, including amidation, esterification, and metal-catalyzed coupling reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns and API intermediate development.

Synthesis

  • Route1
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    • ~%
    • In-stock
      2-Amino-2-(4-hydroxyphenyl)acetic acid|CS-W005226
      938-97-6

    References

    • Bulletin of the Chemical Society of Japan, , vol. 58, # 2 p. 433 - 436
  • Route2
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      6324-01-2
    • ~%
    • In-stock
      2-Amino-2-(4-hydroxyphenyl)acetic acid|CS-W005226
      938-97-6

    References

    • Bulletin of the Chemical Society of Japan, , vol. 60, # 2 p. 649 - 652

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   83.55
  • LogP   0.4766
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

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