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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid

  • CAS No. 178119-93-2

  • Cat. No. CS-0100970
  • Purity≥95%
  • MDL No.MFCD02682475

*For research and further manufacturing use only, not for direct human use.

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid|CS-0100970

Structure of 178119-93-2

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General Information

  • CAS No. 178119-93-2
  • Cat. No. CS-0100970
  • Purity ≥95%
  • MDL No. MFCD02682475
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₁₉NO₅
  • Molecular Weight 389.40
  • Synonym(s) Nα-Fmoc-(4-hydroxy)-D-phenylglycine
  • SMILES O=C([C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=CC=C(O)C=C4)O

Description

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid is a bench-stable, moisture-tolerant chiral building block featuring a fluorenylmethyl carbamate (Fmoc) protecting group. This configuration enables direct incorporation into peptide synthesis workflows, where the pendant phenolic hydroxyl supports downstream derivatization or conjugation.

Application

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid serves as a valuable chiral building block for the synthesis of peptidomimetics and bioactive heterocycles. The Fmoc-protected amino group enables efficient coupling in solid-phase peptide synthesis, while the pendant phenolic hydroxyl offers a site for derivatization or orthogonal functionalization. Its bench-stable crystalline nature facilitates handling and purification, supporting scalable preparation of complex pharmaceutical intermediates.

Synthesis

  • Route1
    • In-stock
      D-4-Hydroxyphenylglycine|CS-0020117
      22818-40-2
    • null|null
      28920-43-6
    • ~%
    • In-stock
      (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid|CS-0100970
      178119-93-2

    References

    • Journal of Medicinal Chemistry, , vol. 48, # 1 p. 56 - 70

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317-H319
Precautionary Statements : P261-P264-P272-P280-P302+P352-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   95.86
  • LogP   4.0566
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   5

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