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Structure of 93748-19-7
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This fluorinated aliphatic acid features a sterically hindered tert-butyl-like core paired with a para-fluorophenyl group, delivering enhanced metabolic stability and lipophilic character. It integrates readily into bioactive scaffolds requiring aromatic substitution and electron-withdrawing effects, enabling efficient access to pharmaceutical intermediates under standard conditions.
2-(4-Fluorophenyl)-2-methylpropanoic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard amide and ester transformations. Its trifluoromethyl-like electronic profile and steric bulk enhance metabolic stability and lipophilicity in drug candidates. The compound exhibits excellent bench stability, facilitates straightforward purification via crystallization, and demonstrates broad compatibility with common coupling reagents in peptide and macrocycle synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: