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CS-W001157 4
Total: USD 88.00

7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine

  • CAS No. 937046-98-5

  • Cat. No. CS-W000773
  • Purity≥95%
  • MDL No.MFCD09033848

*For research and further manufacturing use only, not for direct human use.

7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine|CS-W000773

Structure of 937046-98-5

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General Information

  • CAS No. 937046-98-5
  • Cat. No. CS-W000773
  • Purity ≥95%
  • MDL No. MFCD09033848
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrN₄
  • Molecular Weight 213.04
  • Synonym(s) None
  • SMILES BrC1=CC=C2C(=NC=NN12)N

Description

7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine is a bench-stable heterocyclic building block featuring a brominated pyrrolo[2,1-f][1,2,4]triazine core. This electron-deficient scaffold integrates readily into cross-coupling reactions and serves as a key intermediate in the synthesis of advanced pharmaceutical candidates and functional materials.

Application

7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine serves as a versatile building block for constructing biologically relevant heterocyclic scaffolds. The bromine substituent enables palladium-catalyzed cross-coupling reactions, facilitating the installation of diverse aryl and heteroaryl groups. Its pyrrolo[2,1-f][1,2,4]triazine core provides excellent functional group tolerance and bench stability, making it well-suited for medicinal chemistry campaigns and process-scale synthesis.

Synthesis

  • Route1
    • Pyrrolo[1,2-f][1,2,4]triazin-4-amine Remdesivir  Impurity|CS-0229260
      159326-68-8
    • ~92%
    • In-stock
      7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine|CS-W000773
      937046-98-5

    References

    • BAYER PHARMACEUTICALS CORPORATION Patent: WO2007/64931 A2, 2007 ; Location in patent: Page/Page column 164 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   56.21
  • LogP   1.074
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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