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CS-W001157 4
Total: USD 88.00

2-Chloro-1-(4-chlorophenyl)ethan-1-one

  • CAS No. 937-20-2

  • Cat. No. CS-0238967
  • Purity≥98%
  • MDL No.MFCD00018926

*For research and further manufacturing use only, not for direct human use.

2-Chloro-1-(4-chlorophenyl)ethan-1-one|CS-0238967

Structure of 937-20-2

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General Information

  • CAS No. 937-20-2
  • Cat. No. CS-0238967
  • Purity ≥98%
  • MDL No. MFCD00018926
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆Cl₂O
  • Molecular Weight 189.04
  • Synonym(s) 2,4'-Dichloroacetophenone
  • SMILES C1=C(C=CC(=C1)Cl)C(=O)CCl

Description

2-Chloro-1-(4-chlorophenyl)ethan-1-one features a chlorinated aryl ketone scaffold with enhanced stability and solubility in organic solvents. This electron-deficient carbonyl compound serves as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, enabling efficient coupling reactions under mild conditions.

Application

2-Chloro-1-(4-chlorophenyl)ethan-1-one serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of pharmaceutically relevant heterocycles and functionalized aryl ketones. Its stability under standard reaction conditions and compatibility with nucleophilic substitution, Friedel-Crafts acylation, and Grignard addition reactions make it a practical reagent for medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      676486-15-0
    • ~89%
    • In-stock
      2-Chloro-1-(4-chlorophenyl)ethan-1-one|CS-0238967
      937-20-2

    References

    • Wang, Dengjin; Schwinden, Mark D.; Radesca, Lilian; Patel, Bharat; Kronenthal, David; Huang, Ming-Hsing; Nugent, William A. Journal of Organic Chemistry, 2004 , vol. 69, # 5 p. 1629 - 1633
  • Route2
    • null|null
      99-91-2
    • ~98%
    • In-stock
      2-Chloro-1-(4-chlorophenyl)ethan-1-one|CS-0238967
      937-20-2

    References

    • Chen, Zizhan; Zhou, Bin; Cai, Huihua; Zhu, Wei; Zou, Xinzhuo Green Chemistry, 2009 , vol. 11, # 2 p. 275 - 278
  • Route3
    • null|null
      99-91-2
    • ~41%
    • null|null
      5157-57-3
    • In-stock
      2-Chloro-1-(4-chlorophenyl)ethan-1-one|CS-0238967
      937-20-2

    References

    • Prakash, G.K. Sxurya; Ismail, Rehana; Garcia, Jessica; Panja, Chiradeep; Rasul, Golam; Mathew, Thomas; Olah, George A. Tetrahedron Letters, 2011 , vol. 52, # 11 p. 1217 - 1221

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H303-H317-H318
Precautionary Statements : P261-P272-P280-P302+P352-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.7615
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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