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CS-W001157 4
Total: USD 88.00

3-Bromo-4-(trifluoromethyl)pyridine

  • CAS No. 936841-70-2

  • Cat. No. CS-0197522
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-4-(trifluoromethyl)pyridine|CS-0197522

Structure of 936841-70-2

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General Information

  • CAS No. 936841-70-2
  • Cat. No. CS-0197522
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrF₃N
  • Molecular Weight 225.99
  • Synonym(s) 3-Bromo-4-trifluoromethylpyridine
  • SMILES C1=C(C(=CN=C1)Br)C(F)(F)F

Description

3-Bromo-4-(trifluoromethyl)pyridine features a trifluoromethyl group flanking a brominated pyridine core, delivering enhanced electron-withdrawing character and improved metabolic stability. This configuration enables efficient cross-coupling reactions under standard conditions, facilitating rapid access to complex heteroaromatic architectures in medicinal chemistry and materials science.

Application

3-Bromo-4-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity. The bromo group facilitates efficient C–C bond formation, while the trifluoromethyl substituent enhances metabolic stability and lipophilicity. Its bench-stable nature and compatibility with diverse functional groups make it ideal for constructing complex heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.8629
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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