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CS-W001157 4
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(S)-3-Aminotetrahydrothiophene 1,1-dioxide hydrochloride

  • CAS No. 935455-28-0

  • Cat. No. CS-B0940
  • Purity≥98%
  • MDL No.MFCD28952871

*For research and further manufacturing use only, not for direct human use.

(S)-3-Aminotetrahydrothiophene 1,1-dioxide hydrochloride|CS-B0940

Structure of 935455-28-0

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General Information

  • CAS No. 935455-28-0
  • Cat. No. CS-B0940
  • Purity ≥98%
  • MDL No. MFCD28952871
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₀ClNO₂S
  • Molecular Weight 171.65
  • Synonym(s) (S)-3-AMINOTETRAHYDROTHIOPHENE 1,1-DIOXIDE HCL
  • SMILES N[C@@H](CC1)CS1(=O)=O.[H]Cl

Description

This chiral sulfonamide scaffold delivers a rigid, bench-stable platform for asymmetric synthesis. The (S)-configured tetrahydrothiophene core bears a protonated amine and two sulfonyl oxygens, enabling strong hydrogen bonding and enhanced solubility in aqueous-organic mixtures. Ideal for medicinal chemistry campaigns requiring stereocontrolled heterocyclic motifs with improved metabolic stability.

Application

(S)-3-Aminotetrahydrothiophene 1,1-dioxide hydrochloride serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of sulfonamide-containing heterocycles. Its stable, bench-ready form facilitates straightforward handling and purification, while the amino group supports diverse functionalization including coupling reactions and derivatization. The sulfone moiety imparts enhanced metabolic stability and polarity, making it well-suited for constructing bioactive scaffolds in drug discovery programs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   60.16
  • LogP   -0.446
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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