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CS-W001157 4
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4-Fluoro-3-hydroxybenzyl alcohol

  • CAS No. 934241-78-8

  • Cat. No. CS-0157084
  • Molecule weight142.13
  • Purity≥98%
  • MDL No.MFCD12031832

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-3-hydroxybenzyl alcohol|CS-0157084

Structure of 934241-78-8

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General Information

  • CAS No. 934241-78-8
  • Cat. No. CS-0157084
  • Purity ≥98%
  • MDL No. MFCD12031832
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FO₂
  • Molecular Weight 142.13
  • Synonym(s) 2-Fluoro-5-(hydroxymethyl)phenol
  • SMILES C1=CC(=C(C=C1CO)O)F

Description

4-Fluoro-3-hydroxybenzyl alcohol features a hydroxyl group flanked by electron-withdrawing fluorine and aromatic ring functionalities, enabling direct functionalization in synthetic sequences. This bench-stable phenolic derivative integrates readily into bioactive molecule scaffolds, offering controlled polarity and hydrogen-bonding capacity for medicinal chemistry applications.

Application

4-Fluoro-3-hydroxybenzyl alcohol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl and benzylic alcohol sites. Its ortho-fluoro substituent enhances metabolic stability and facilitates downstream coupling reactions. The molecule exhibits excellent bench stability, ease of purification, and compatibility with standard protecting group strategies, making it well-suited for the synthesis of bioactive heterocycles and API intermediates.

Synthesis

  • Route1

    References

    • Dainippon Sumitomo Pharma Co. Ltd.; AstraZeneca AB Patent: US2011/136801 A1, 2011 ; Location in patent: Page/Page column 64 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.0236
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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