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1-Methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

  • CAS No. 933733-84-7

  • Cat. No. CS-0186351
  • Molecule weight149.19
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine|CS-0186351

Structure of 933733-84-7

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General Information

  • CAS No. 933733-84-7
  • Cat. No. CS-0186351
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁N₃
  • Molecular Weight 149.19
  • Synonym(s) 1-methyl-3,4-dihydro-2H-pyrido[2,3-b]pyrazine
  • SMILES CN1CCNC2=C1C=CC=N2

Description

1-Methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine is a heterocyclic scaffold featuring a fused pyridine-pyrazine core with a methyl group at the nitrogen bridgehead. This electron-rich system offers enhanced solubility and stability under standard bench conditions, enabling direct incorporation into medicinal chemistry libraries. The rigid, planar geometry supports π-stacking interactions in target binding studies.

Application

1-Methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of complex nitrogen-containing scaffolds. Its functionalized core exhibits robust bench stability and compatibility with standard coupling reactions, facilitating efficient derivatization for target-oriented synthesis. The molecule functions as a key intermediate in the development of bioactive compounds, particularly within kinase inhibitor and CNS-targeted therapeutic programs.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

  • TPSA   28.16
  • LogP   0.9433
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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