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CS-W001157 4
Total: USD 88.00

3-(Thiazol-5-yl)propanoic acid

  • CAS No. 933724-95-9

  • Cat. No. CS-0159433
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-(Thiazol-5-yl)propanoic acid|CS-0159433

Structure of 933724-95-9

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Description

This thiazole-containing carboxylic acid integrates a rigid, electron-deficient heterocycle with a flexible aliphatic chain, enabling robust conjugation in bioactive molecule design. The para-positioned thiazole enhances metabolic stability and modulates lipophilicity for improved membrane permeability. This scaffold serves as a key building block in medicinal chemistry campaigns targeting kinase inhibitors and antimicrobial agents.

Application

3-(Thiazol-5-yl)propanoic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its thiazole moiety provides robust metabolic stability and favorable pharmacophore characteristics, while the pendant carboxylic acid enables straightforward derivatization via amide, ester, or acyl chloride formation. The compound exhibits good bench stability and is compatible with standard coupling reactions, facilitating efficient incorporation into complex molecular architectures.

General Information

  • CAS No. 933724-95-9
  • Cat. No. CS-0159433
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₂S
  • Molecular Weight 157.19
  • Synonym(s) 5-Thiazolepropanoic acid
  • SMILES O=C(O)CCC1=CN=CS1

Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.1603
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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