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CS-W001157 4
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3-(Thiazol-5-yl)propanoic acid

  • CAS No. 933724-95-9

  • Cat. No. CS-0159433
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Thiazol-5-yl)propanoic acid|CS-0159433

Structure of 933724-95-9

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General Information

  • CAS No. 933724-95-9
  • Cat. No. CS-0159433
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₂S
  • Molecular Weight 157.19
  • Synonym(s) 5-Thiazolepropanoic acid
  • SMILES O=C(O)CCC1=CN=CS1

Description

This thiazole-containing carboxylic acid integrates a rigid, electron-deficient heterocycle with a flexible aliphatic chain, enabling robust conjugation in bioactive molecule design. The para-positioned thiazole enhances metabolic stability and modulates lipophilicity for improved membrane permeability. This scaffold serves as a key building block in medicinal chemistry campaigns targeting kinase inhibitors and antimicrobial agents.

Application

3-(Thiazol-5-yl)propanoic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its thiazole moiety provides robust metabolic stability and favorable pharmacophore characteristics, while the pendant carboxylic acid enables straightforward derivatization via amide, ester, or acyl chloride formation. The compound exhibits good bench stability and is compatible with standard coupling reactions, facilitating efficient incorporation into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.1603
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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