Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Ethyl 6-chloroindole-2-carboxylate

  • CAS No. 27034-51-1

  • Cat. No. CS-W005122
  • Purity≥98%
  • MDL No.MFCD03084731

*For research and further manufacturing use only, not for direct human use.

Ethyl 6-chloroindole-2-carboxylate|CS-W005122

Structure of 27034-51-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 27034-51-1
  • Cat. No. CS-W005122
  • Purity ≥98%
  • MDL No. MFCD03084731
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀ClNO₂
  • Molecular Weight 223.66
  • Synonym(s) Ethyl-6-chlor-1H-indol-2-carboxylat
  • SMILES ClC1=CC=C2C(=C1)[NH]C(=C2)C(=O)OCC

Description

Ethyl 6-chloroindole-2-carboxylate features a chlorinated indole core with a carboxylate ester at the C2 position, enabling direct integration into heterocyclic scaffolds. The electron-deficient indole ring enhances reactivity in transition-metal-catalyzed couplings, while the ethyl ester facilitates downstream functionalization. This bench-stable derivative serves as a key intermediate in medicinal chemistry and materials synthesis.

Application

Ethyl 6-chloroindole-2-carboxylate serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C6 position of the indole scaffold. Its chloro group facilitates palladium-catalyzed cross-coupling reactions, while the ester functionality supports selective reduction or hydrolysis to access carboxylic acid derivatives. The compound exhibits good bench stability and compatibility with standard synthetic workflows, making it well-suited for the construction of complex heterocyclic architectures and API intermediates.

Synthesis

  • Route1
    • null|null
      24513-05-1
    • ~53%
    • In-stock
      Ethyl 6-chloroindole-2-carboxylate|CS-W005122
      27034-51-1

    References

    • Wang, Rui; Shi, Hong-Fan; Zhao, Jing-Feng; He, Yan-Ping; Zhang, Hong-Bin; Liu, Jian-Ping Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1760 - 1762
  • Route2
    • null|null
      540523-98-6
    • ~50%
    • In-stock
      Ethyl 6-chloroindole-2-carboxylate|CS-W005122
      27034-51-1

    References

    • Gore, Vivek; Patel, Pranav; Chang, Chih-Tsung; Sivendran, Sashikala; Kang, Namin; Ouedraogo, Yannick P.; Gravel, Sylvie; Powell, William S.; Rokach, Joshua Journal of Medicinal Chemistry, 2013 , vol. 56, # 9 p. 3725 - 3732
  • Route3

    References

    • Sanz, Roberto; Escribano, Jaime; Pedrosa, Maria R.; Aguado, Rafael; Arnaiz, Francisco J. Advanced Synthesis and Catalysis, 2007 , vol. 349, # 4-5 p. 713 - 718

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   42.09
  • LogP   2.998
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • Ethyl 6-chloroindole-2-carboxylate sigmaEthyl 6-chloroindole-2-carboxylate manufacturerEthyl 6-chloroindole-2-carboxylate priceEthyl 6-chloroindole-2-carboxylate structureEthyl 6-chloroindole-2-carboxylate SDSbuy Ethyl 6-chloroindole-2-carboxylateEthyl 6-chloroindole-2-carboxylate supplierEthyl 6-chloroindole-2-carboxylate usesEthyl 6-chloroindole-2-carboxylate molecular weightprice of Ethyl 6-chloroindole-2-carboxylateEthyl 6-chloroindole-2-carboxylate chemical name formula of Ethyl 6-chloroindole-2-carboxylate
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label