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CS-W001157 4
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2-Ethylthiazole-5-carbaldehyde

  • CAS No. 933683-87-5

  • Cat. No. CS-0187890
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Ethylthiazole-5-carbaldehyde|CS-0187890

Structure of 933683-87-5

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General Information

  • CAS No. 933683-87-5
  • Cat. No. CS-0187890
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NOS
  • Molecular Weight 141.19
  • Synonym(s) 5-Thiazolecarboxaldehyde, 2-ethyl-
  • SMILES CCC1=NC=C(C=O)S1

Description

2-Ethylthiazole-5-carbaldehyde features a thiazole ring bearing an ethyl substituent at the 2-position and a formyl group at the 5-position, delivering a potent electrophilic handle. This scaffold integrates readily into heterocyclic synthesis, offering enhanced solubility and stability compared to analogs. The aldehyde functionality enables efficient coupling reactions in medicinal chemistry and materials science applications.

Application

2-Ethylthiazole-5-carbaldehyde serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient construction of thiazole-based pharmacophores. Its aldehyde functionality facilitates reductive amination, Grignard additions, and condensation reactions with amines or hydrazines under standard conditions. The ethyl substituent enhances solubility and modulates electronic properties without compromising bench stability. This compound functions reliably in multistep syntheses requiring orthogonal functional group compatibility and offers straightforward purification via crystallization or flash chromatography.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.518
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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