Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1,3-Difluoro-5-methyl-2-nitrobenzene

  • CAS No. 932373-92-7

  • Cat. No. CS-W008674
  • Purity≥97%
  • MDL No.MFCD15527695

*For research and further manufacturing use only, not for direct human use.

1,3-Difluoro-5-methyl-2-nitrobenzene|CS-W008674

Structure of 932373-92-7

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 932373-92-7
  • Cat. No. CS-W008674
  • Purity ≥97%
  • MDL No. MFCD15527695
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂NO₂
  • Molecular Weight 173.12
  • Synonym(s) 3,5-Difluoro-4-nitrotoluene; 13-DIFLUORO-5-METHYL-2-NITROBENZENE
  • SMILES O=[N+](C1=C(F)C=C(C)C=C1F)[O-]

Description

1,3-Difluoro-5-methyl-2-nitrobenzene features a trifunctional aromatic core with orthogonal reactivity. The electron-deficient ring supports nucleophilic substitution, while the methyl group provides a handle for further functionalization. This bench-stable scaffold enables streamlined access to complex heterocycles and bioactive intermediates in medicinal chemistry.

Application

1,3-Difluoro-5-methyl-2-nitrobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling selective functionalization via palladium-catalyzed cross-coupling due to its ortho-fluorine reactivity. The methyl and nitro groups provide orthogonal handles for further derivatization, while the difluoro substitution enhances metabolic stability and modulates electronic properties. Bench-stable and compatible with standard purification protocols, it facilitates efficient access to complex heterocyclic scaffolds and bioactive molecules.

Synthesis

  • Route1
    • 2-(3,5-Difluoro-4-nitrophenyl)acetic acid|CS-1045842
      932373-91-6
    • ~%
    • In-stock
      1,3-Difluoro-5-methyl-2-nitrobenzene|CS-W008674
      932373-92-7

    References

    • WO2008/119720 A1, ; Page/Page column 57 ; WO 2008/119720 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   43.14
  • LogP   2.18142
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 1,3-Difluoro-5-methyl-2-nitrobenzene sigma1,3-Difluoro-5-methyl-2-nitrobenzene manufacturer1,3-Difluoro-5-methyl-2-nitrobenzene price1,3-Difluoro-5-methyl-2-nitrobenzene structure1,3-Difluoro-5-methyl-2-nitrobenzene SDSbuy 1,3-Difluoro-5-methyl-2-nitrobenzene1,3-Difluoro-5-methyl-2-nitrobenzene supplier1,3-Difluoro-5-methyl-2-nitrobenzene uses1,3-Difluoro-5-methyl-2-nitrobenzene molecular weightprice of 1,3-Difluoro-5-methyl-2-nitrobenzene1,3-Difluoro-5-methyl-2-nitrobenzene chemical name formula of 1,3-Difluoro-5-methyl-2-nitrobenzene
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label