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CS-W001157 4
Total: USD 88.00

5-Bromo-3,4-dimethylpyridin-2-amine

  • CAS No. 374537-97-0

  • Cat. No. CS-W015564
  • Purity≥95%
  • MDL No.MFCD02093947

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3,4-dimethylpyridin-2-amine|CS-W015564

Structure of 374537-97-0

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General Information

  • CAS No. 374537-97-0
  • Cat. No. CS-W015564
  • Purity ≥95%
  • MDL No. MFCD02093947
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉BrN₂
  • Molecular Weight 201.06
  • Synonym(s) 5-Bromo-3,4-dimethyl-2-pyridinamine
  • SMILES NC1=NC=C(Br)C(C)=C1C

Description

5-Bromo-3,4-dimethylpyridin-2-amine features a brominated pyridine core with two methyl groups at the 3- and 4-positions, enhancing electron density and steric profile. This configuration enables efficient coupling in transition-metal-catalyzed reactions, particularly in Pd-mediated cross-couplings. The compound exhibits bench-stable handling characteristics and integrates readily into complex heterocyclic architectures used in medicinal chemistry and materials science.

Application

5-Bromo-3,4-dimethylpyridin-2-amine serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. The bromine atom enables reliable Suzuki, Stille, and Negishi couplings, while the pyridin-2-amine functionality offers orthogonal reactivity for further derivatization. Bench-stable and readily purified, it facilitates efficient access to substituted heterocycles and API scaffolds under standard reaction conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.04314
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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