tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride

Name: tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride
Brand: ChemScene
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CAS No. 929302-18-1
Cat. No. CS-B0192
Purity≥95%
MDL No.MFCD09835396

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FedEx Limited Quantities Ground	$0.00
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tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride|CS-B0192

Structure of 929302-18-1

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General Information

CAS No. 929302-18-1
Cat. No. CS-B0192
Purity ≥95%
MDL No. MFCD09835396
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₃ClN₂O₂
Molecular Weight 262.78
Synonym(s) None
SMILES O=C(N1CC2(CCNCC2)C1)OC(C)(C)C.Cl

Description

tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride features a rigid spirocyclic core with two nitrogen atoms at strategic positions, enabling efficient integration into complex molecular architectures. The tert-butyl ester group offers enhanced stability and solubility in organic media, while the hydrochloride salt improves crystallinity and handling under standard bench conditions. This combination supports streamlined synthetic access to biologically active scaffolds.

Application

tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride serves as a versatile spirocyclic scaffold for medicinal chemistry applications, offering orthogonal nitrogen functionality and robust bench stability. The tert-butyl ester enables straightforward deprotection under mild acidic conditions, while the hydrochloride salt enhances solubility and crystallinity. It functions effectively in standard coupling reactions, facilitating the construction of complex heterocyclic architectures with predictable stereochemical outcomes.

Synthesis

Route1
- In-stock
  
  929301-99-5
- ~%
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  929302-18-1
References
- ASTRAZENECA AB Patent: WO2007/30061 A1, 2007 ; Location in patent: Page/Page column 91; 92 ; WO 2007/030061 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 41.57
LogP 2.0287
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

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tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride

CAS No. 929302-18-1

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