1-Phenylpyrrolidin-3-amine

Name: 1-Phenylpyrrolidin-3-amine
Brand: ChemScene
Availability: InStock
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CAS No. 18471-41-5
Cat. No. CS-0258755
Molecule weight162.23
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 18471-41-5

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General Information

CAS No. 18471-41-5
Cat. No. CS-0258755
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₄N₂
Molecular Weight 162.23
Synonym(s) 3-Pyrrolidinamine,1-phenyl
SMILES C1=CC=C(C=C1)N2CCC(C2)N

Description

1-Phenylpyrrolidin-3-amine delivers a rigid, electron-rich scaffold ideal for medicinal chemistry applications. This tertiary amine integrates seamlessly into bioactive molecules, offering enhanced solubility and metabolic stability. The phenyl ring enhances π-stacking potential, while the pyrrolidine core provides conformational flexibility for target engagement.

Application

1-Phenylpyrrolidin-3-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its tertiary amine functionality offers favorable reactivity for alkylation, acylation, and coupling reactions, while the phenyl group enhances metabolic stability and target affinity. Bench-stable and readily purified by standard techniques, it functions effectively in multistep syntheses requiring robust functional group tolerance.

Synthesis

Route1
- 108-86-1
- 79286-79-6
- ~82%
- In-stock
  
  18471-41-5
References
- Cabello-Sanchez, Noemi; Jean, Ludovic; Maddaluno, Jacques; Lasne, Marie-Claire; Rouden, Jacques Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2030 - 2039
Route2
- In-stock
  
  591-50-4
- 79286-79-6
- ~72%
- In-stock
  
  18471-41-5
References
- Cabello-Sanchez, Noemi; Jean, Ludovic; Maddaluno, Jacques; Lasne, Marie-Claire; Rouden, Jacques Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2030 - 2039

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 29.26
LogP 1.224
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-Phenylpyrrolidin-3-amine

CAS No. 18471-41-5

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