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CS-W001157 4
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Sulfo-SMCC sodium

  • CAS No. 92921-24-9

  • Cat. No. CS-7553
  • Molecule weight436.37
  • Purity≥95%
  • MDL No.MFCD00054978

*For research and further manufacturing use only, not for direct human use.

Sulfo-SMCC sodium|CS-7553

Structure of 92921-24-9

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General Information

  • CAS No. 92921-24-9
  • Cat. No. CS-7553
  • Purity ≥95%
  • MDL No. MFCD00054978
  • Storage 4°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₇N₂NaO₉S
  • Molecular Weight 436.37
  • Synonym(s) None
  • SMILES O=C(C1CCC(CN2C(C=CC2=O)=O)CC1)ON3C(C(S(=O)(O[Na])=O)CC3=O)=O

Description

Sulfo-SMCC (sodium) is a water-soluble, amine-reactive crosslinker featuring a maleimide group for thiol conjugation. This bifunctional reagent enables site-specific protein labeling and antibody-drug conjugate formation under physiological conditions. The sulfonated backbone enhances aqueous solubility while maintaining stability during storage and handling.

Application

Sulfo-SMCC (sodium) serves as a water-soluble, cleavable crosslinker for protein conjugation and immunoassay applications. Its sulfonate group enhances aqueous solubility, while the maleimide moiety enables selective reaction with reduced cysteine residues. The amine-reactive NHS ester facilitates coupling to primary amines on proteins or biomolecules. This bifunctional reagent enables site-specific bioconjugation under physiological conditions and is widely used in antibody-drug conjugate development and probe labeling workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   144.43
  • LogP   -1.2666
  • H_Acceptors   9
  • H_Donors   0
  • Rotatable_Bonds   6

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