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CS-W001157 4
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Sulfo-GMBS

  • CAS No. 185332-92-7

  • Cat. No. CS-0030577
  • Molecule weight382.28
  • Purity≥95%
  • MDL No.MFCD17215919

*For research and further manufacturing use only, not for direct human use.

Sulfo-GMBS|CS-0030577

Structure of 185332-92-7

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General Information

  • CAS No. 185332-92-7
  • Cat. No. CS-0030577
  • Purity ≥95%
  • MDL No. MFCD17215919
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₁N₂NaO₉S
  • Molecular Weight 382.28
  • Synonym(s) Sulfo-N-succinimidyl 4-Maleimidobutyrate Sodium Salt
  • SMILES O=C(CCCN1C(C=CC1=O)=O)ON2C(CC(S(=O)(O[Na])=O)C2=O)=O

Description

Sulfo-GMBS is a water-soluble, maleimide-functional crosslinker designed for bioconjugation under physiological conditions. This reagent features a sulfonate group that enhances solubility in aqueous buffers while maintaining high reactivity with thiol-containing biomolecules. The maleimide moiety enables efficient, site-specific coupling to cysteine residues in proteins and peptides. Ideal for antibody-drug conjugates and protein labeling workflows.

Application

Sulfo-GMBS serves as a water-soluble, amine-reactive crosslinker for bioconjugation applications. Its sulfhydryl-reactive maleimide group enables site-specific labeling of thiol-containing biomolecules, while the charged sulfonate moiety enhances solubility in aqueous buffers. The reagent facilitates efficient conjugation under physiological conditions and is well-suited for protein-protein, protein-oligonucleotide, and antibody-drug conjugation workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   144.43
  • LogP   -2.2928
  • H_Acceptors   9
  • H_Donors   0
  • Rotatable_Bonds   7

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