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CS-W001157 4
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3-Bromo-6-chloropyridine-2-carboxylic acid

  • CAS No. 929000-66-8

  • Cat. No. CS-W005193
  • Purity≥95%
  • MDL No.MFCD09258777

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-chloropyridine-2-carboxylic acid|CS-W005193

Structure of 929000-66-8

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General Information

  • CAS No. 929000-66-8
  • Cat. No. CS-W005193
  • Purity ≥95%
  • MDL No. MFCD09258777
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClNO₂
  • Molecular Weight 236.45
  • Synonym(s) 3-bromo-6-chloro-pyridine-2-carboxylic acid
  • SMILES O=C(C1=NC(Cl)=CC=C1Br)O

Description

3-Bromo-6-chloropyridine-2-carboxylic acid features a pyridine core functionalized with bromo, chloro, and carboxylic acid groups at strategic positions, enabling direct incorporation into cross-coupling and bioconjugation workflows. The electron-deficient ring enhances reactivity in palladium-catalyzed transformations, while the carboxylic acid facilitates derivatization or salt formation for improved solubility and handling.

Application

3-Bromo-6-chloropyridine-2-carboxylic acid serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen functionality. The carboxylic acid group facilitates direct derivatization or activation for amide bond formation, while the bromo and chloro substituents provide complementary reactivity for sequential functionalization. Its bench-stable crystalline form supports straightforward handling and purification, making it well-suited for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.1957
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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