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CS-W001157 4
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2-(3-Bromophenoxy)ethan-1-amine

  • CAS No. 926211-83-8

  • Cat. No. CS-0018040
  • Molecule weight216.08
  • Purity≥95%
  • MDL No.MFCD09042556

*For research and further manufacturing use only, not for direct human use.

2-(3-Bromophenoxy)ethan-1-amine|CS-0018040

Structure of 926211-83-8

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General Information

  • CAS No. 926211-83-8
  • Cat. No. CS-0018040
  • Purity ≥95%
  • MDL No. MFCD09042556
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀BrNO
  • Molecular Weight 216.08
  • Synonym(s) 2-(3-Bromophenoxy)ethylamine
  • SMILES BrC1=CC(OCCN)=CC=C1

Description

2-(3-Bromophenoxy)ethan-1-amine features a brominated phenoxy linker that enhances electronic modulation and facilitates downstream functionalization. This bench-stable, moisture-tolerant amine integrates readily into bioactive molecule scaffolds, offering high reactivity in nucleophilic substitution and coupling processes under standard conditions.

Application

2-(3-Bromophenoxy)ethan-1-amine serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its bromo substituent enables facile Suzuki-Miyaura and Stille coupling reactions, while the primary amine functionality supports efficient derivatization via acylation, alkylation, or reductive amination. The compound exhibits good bench stability and is compatible with standard purification techniques, facilitating integration into multi-step synthetic sequences for medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      938642-05-8
    • ~75%
    • In-stock
      2-(3-Bromophenoxy)ethan-1-amine|CS-0018040
      926211-83-8

    References

    • ACUCELA, INC. Patent: WO2009/5794 A2, 2009 ; Location in patent: Page/Page column 125-126 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H319
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.7866
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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