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CS-W001157 4
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3-(Pyridin-2-yl)-1H-pyrazol-5-amine

  • CAS No. 92352-29-9

  • Cat. No. CS-0070349
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Pyridin-2-yl)-1H-pyrazol-5-amine|CS-0070349

Structure of 92352-29-9

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General Information

  • CAS No. 92352-29-9
  • Cat. No. CS-0070349
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₄
  • Molecular Weight 160.18
  • Synonym(s) 5-Pyridin-2-yl-2H-pyrazol-3-ylamine
  • SMILES NC1=CC(C2=CC=CC=N2)=NN1

Description

3-(Pyridin-2-yl)-1H-pyrazol-5-amine features a fused pyrazole and pyridine core, delivering enhanced electron density at the 5-position for targeted functionalization. This bench-stable scaffold integrates readily into bioactive molecules, offering improved solubility and metabolic resilience in medicinal chemistry applications.

Application

3-(Pyridin-2-yl)-1H-pyrazol-5-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to biologically relevant scaffolds. Its pyrazole core exhibits robust bench stability and tolerates diverse functional groups, facilitating coupling reactions and metal-catalyzed transformations. The pyridyl moiety enhances solubility and provides a site for further derivatization, making it particularly useful in the synthesis of kinase inhibitors and other targeted therapeutics.

Synthesis

  • Route1

    References

    • WO2009/111279 A1, ; Page/Page column 111 ; WO 2009/111279 A1
  • Route2

    References

    • WO2011/126903 A2, ; WO 2011/126903 A2
  • Route3

    References

    • WO2011/126903 A2, ; WO 2011/126903 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   67.59
  • LogP   1.0539
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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