CRBN ligand-881

Name: CRBN ligand-881
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CAS No. 92137-90-1
Cat. No. CS-0498819
Purity≥97%
MDL No.MFCD24561931

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Type	HazMat Fee
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FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Structure of 92137-90-1

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General Information

CAS No. 92137-90-1
Cat. No. CS-0498819
Purity ≥97%
MDL No. MFCD24561931
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₂N₂O₂
Molecular Weight 204.23
Synonym(s) None
SMILES O=C1NC(=O)C(C2=CC=C(N)C=C2)CC1

Description

3-(4-Aminophenyl)piperidine-2,6-dione features a conjugated arylamine linked to a cyclic diketone scaffold, enabling direct integration into bioactive molecule design. This electron-rich aromatic amine facilitates coupling reactions under mild conditions, while the diketone moiety supports metal coordination and cyclization pathways. Bench-stable and moisture-tolerant, it serves as a versatile intermediate in medicinal chemistry and materials synthesis.

Application

3-(4-Aminophenyl)piperidine-2,6-dione serves as a versatile building block for heterocyclic synthesis, enabling efficient access to biologically relevant scaffolds. Its conjugated enone system and pendant aniline functionality facilitate Michael additions, reductive amination, and transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability and is readily purified by crystallization, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Synthesis

Route1
- 92137-91-2
- ~%
- In-stock
  
  92137-90-1
References
- Hartmann, Rolf W.; Batzl, Christine Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1362 - 1369
Route2
- In-stock
  
  14149-34-9
- ~%
- In-stock
  
  92137-90-1
References
- Hartmann, Rolf W.; Batzl, Christine Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1362 - 1369
Route3
- 91137-66-5
- ~%
- In-stock
  
  92137-90-1
References
- Hartmann, Rolf W.; Batzl, Christine Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1362 - 1369

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

Quality Control

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Computational Chemistry Data

TPSA 72.19
LogP 0.6792
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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CRBN ligand-881

CAS No. 92137-90-1

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