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CS-W001157 4
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(6-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyridin-3-yl)boronic acid

  • CAS No. 919347-67-4

  • Cat. No. CS-0060952
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(6-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyridin-3-yl)boronic acid|CS-0060952

Structure of 919347-67-4

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General Information

  • CAS No. 919347-67-4
  • Cat. No. CS-0060952
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₂BN₃O₄
  • Molecular Weight 307.15
  • Synonym(s) (6-(4-(tert-Butoxycarbonyl)
  • SMILES CC(C)(C)OC(=O)N1CCN(CC1)C2=NC=C(C=C2)B(O)O

Description

This boronate moiety integrates a tert-butoxycarbonyl-protected piperazine ring at the 6-position of a pyridine scaffold, enabling facile downstream functionalization. The electron-deficient pyridine core enhances reactivity in Suzuki-Miyaura couplings, while the bench-stable boronic acid group tolerates standard handling conditions and moisture exposure.

Application

(6-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyridin-3-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. The protected piperazine moiety offers enhanced stability and orthogonal deprotection compatibility, while the boronic acid functionality facilitates reliable coupling with aryl halides and triflates. Its bench-stable solid form simplifies handling and purification, making it well-suited for iterative synthesis of complex heterocyclic scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   86.13
  • LogP   -0.1815
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   2

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