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Structure of 918483-35-9
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4-Iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole features a trifluoroethyl group that imparts enhanced metabolic stability and lipophilicity, while the iodine atom enables efficient late-stage functionalization via cross-coupling. This combination delivers a robust scaffold for medicinal chemistry campaigns targeting bioactive heterocycles.
4-Iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole serves as a versatile building block for the synthesis of bioactive heterocycles, enabling palladium-catalyzed cross-coupling reactions with high efficiency. The trifluoroethyl group enhances metabolic stability and modulates lipophilicity, while the iodopyrazole moiety provides excellent reactivity in Suzuki-Miyaura and Buchwald-Hartwig couplings. Bench-stable and readily purified by flash chromatography, it functions reliably in medicinal chemistry campaigns targeting CNS and oncology therapeutics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H315-H319-H332-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: