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CS-W001157 4
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5,6,7,8-Tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid

  • CAS No. 917364-11-5

  • Cat. No. CS-W005993
  • Purity≥95%
  • MDL No.MFCD10566765

*For research and further manufacturing use only, not for direct human use.

5,6,7,8-Tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid|CS-W005993

Structure of 917364-11-5

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General Information

  • CAS No. 917364-11-5
  • Cat. No. CS-W005993
  • Purity ≥95%
  • MDL No. MFCD10566765
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂O₂
  • Molecular Weight 166.18
  • Synonym(s) Imidazo[1,2-a]pyridine-2-carboxylic acid, 5,6,7,8-tetrahydro-
  • SMILES O=C(C1=CN2CCCCC2=N1)O

Description

This tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid scaffold integrates a rigid heterocyclic core with a carboxylic acid handle, enabling direct conjugation in medicinal chemistry. The fused ring system imparts metabolic stability and favorable pharmacokinetic properties, while the acidic functionality supports salt formation and solubility enhancement.

Application

5,6,7,8-Tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to biologically relevant scaffolds. Its carboxylic acid functionality facilitates direct coupling reactions and derivatization, while the saturated imidazopyridine core provides structural rigidity and favorable pharmacokinetic properties. The compound exhibits good bench stability and compatibility with standard purification methods, supporting its use in multi-step syntheses and library generation.

Synthesis

  • Route1

    References

    • ASTRAZENECA AB Patent: WO2007/108750 A1, 2007 ; Location in patent: Page/Page column 77 ; WO 2007/108750 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   0.9176
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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