Lot numbers can be found on the outside label of a product:
6-Bromo-3-methoxypyridin-2-amine
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CAS No. 916737-77-4
- Cat. No. CS-W018975
- Purity≥97%
- MDL No.MFCD15142726
*For research and further manufacturing use only, not for direct human use.
Structure of 916737-77-4
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General Information
- CAS No. 916737-77-4
- Cat. No. CS-W018975
- Purity ≥97%
- MDL No. MFCD15142726
- Storage RT, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₇BrN₂O
- Molecular Weight 203.04
- Synonym(s) 6-Bromo-3-methoxy-pyridin-2-ylamine
- SMILES COC1=CC=C(Br)N=C1N
Description
6-Bromo-3-methoxypyridin-2-amine features a brominated pyridine core with a methoxy group at C3 and an amino substituent at C2, delivering a versatile scaffold for medicinal chemistry. The electron-deficient heterocycle facilitates palladium-catalyzed coupling reactions, while the methoxy moiety enhances solubility and modulates electronic properties. This bench-stable compound serves as a key intermediate in the synthesis of kinase inhibitors and functionalized pharmaceuticals.
Application
6-Bromo-3-methoxypyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined bromo and amino functionalities. The methoxy group enhances solubility and modulates electronic properties, while the compound exhibits excellent bench stability and compatibility with standard synthetic workflows. Its orthogonally reactive sites facilitate efficient diversification in heterocyclic scaffold development.
Synthesis
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Route1
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In-stock
916737-76-3 - ~%
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In-stock
916737-77-4
References
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HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; CHRISTOPHER, John Andrew; TEHAN, Benjamin Gerald; KLAIR, Sukhbinder Singh; AVES, Sarah Joanne Patent: WO2014/6402 A1, 2014 ; Location in patent: Page/Page column 85 ;
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Route2
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In-stock
15128-82-2 - ~%
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In-stock
916737-77-4
References
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HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; CHRISTOPHER, John Andrew; TEHAN, Benjamin Gerald; KLAIR, Sukhbinder Singh; AVES, Sarah Joanne Patent: WO2014/6402 A1, 2014 ;
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Route3
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In-stock
443956-08-9 - ~%
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In-stock
916737-77-4
References
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HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; CHRISTOPHER, John Andrew; TEHAN, Benjamin Gerald; KLAIR, Sukhbinder Singh; AVES, Sarah Joanne Patent: WO2014/6402 A1, 2014 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 48.14
- LogP 1.4349
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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