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CS-W001157 4
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1-(Thiazol-5-yl)ethan-1-one

  • CAS No. 91516-28-8

  • Cat. No. CS-0171646
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Thiazol-5-yl)ethan-1-one|CS-0171646

Structure of 91516-28-8

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General Information

  • CAS No. 91516-28-8
  • Cat. No. CS-0171646
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NOS
  • Molecular Weight 127.16
  • Synonym(s) 1-Thiazol-5-yl-ethanone
  • SMILES CC(=O)C1=CN=CS1

Description

1-(Thiazol-5-yl)ethan-1-one features a thiazole ring fused to an acetyl group, delivering a highly electron-deficient carbonyl center. This configuration enables direct participation in nucleophilic addition and cross-coupling reactions. The compound exhibits excellent bench stability and solubility in common organic solvents, facilitating seamless integration into synthetic workflows for heterocyclic and pharmaceutical intermediates.

Application

1-(Thiazol-5-yl)ethan-1-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of thiazole-containing scaffolds. Its ketone functionality facilitates nucleophilic addition and condensation reactions, while the aromatic thiazole ring provides metabolic stability and favorable pharmacokinetic properties. The compound exhibits good bench stability and is compatible with standard purification methods, making it suitable for high-throughput synthesis and process-scale applications.

Synthesis

  • Route1
    • N-Methoxy-N-methyl thiazole-5-carboxamide|CS-0211256
      898825-89-3
    • ~%
    • In-stock
      1-(Thiazol-5-yl)ethan-1-one|CS-0171646
      91516-28-8

    References

    • WO2006/76529 A1, ; Page/Page column 158 ;
  • Route2
    • 5-(Trimethylsilyl)thiazole|CS-0158140
      79265-36-4
    • null|null
      75-36-5
    • ~29%
    • In-stock
      1-(Thiazol-5-yl)ethan-1-one|CS-0171646
      91516-28-8

    References

    • Dondoni, Alessandro; Fantin, Giancarlo; Fogagnolo, Marco; Medici, Alessandro; Pedrini, Paola Journal of Organic Chemistry, 1988 , vol. 53, # 8 p. 1748 - 1761
  • Route3
    • null|null
      115-08-2
    • null|null
      87005-15-0
    • ~%
    • In-stock
      1-(Thiazol-5-yl)ethan-1-one|CS-0171646
      91516-28-8

    References

    • Zhurnal Obshchei Khimii, , vol. 29, p. 2330,2336; engl. Ausg. S. 2294, 2299

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.3457
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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