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CS-W001157 4
Total: USD 88.00

5-Chloroisoindoline hydrochloride

  • CAS No. 912999-79-2

  • Cat. No. CS-W005214
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Chloroisoindoline hydrochloride|CS-W005214

Structure of 912999-79-2

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General Information

  • CAS No. 912999-79-2
  • Cat. No. CS-W005214
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉Cl₂N
  • Molecular Weight 190.07
  • Synonym(s) None
  • SMILES ClC1=CC=C2CNCC2=C1.Cl

Description

5-Chloroisoindoline hydrochloride offers a stable, moisture-tolerant platform for constructing complex heterocycles in medicinal chemistry. The chlorinated isoindoline core integrates readily into diverse synthetic routes, enabling efficient access to bioactive scaffolds under standard conditions.

Application

5-Chloroisoindoline hydrochloride serves as a stable, bench-ready building block for the synthesis of isoindoline-based pharmaceutical intermediates. Its chlorine substituent enables direct electrophilic substitution or palladium-catalyzed coupling reactions, while the protonated nitrogen enhances solubility and facilitates purification. This compound functions reliably in standard heterocyclic transformations and provides access to diverse bioactive scaffolds used in medicinal chemistry.

Synthesis

  • Route1
    • 5-Chloro-2-tosylisoindoline|CS-0719144
      127168-77-8
    • ~%
    • In-stock
      5-Chloroisoindoline hydrochloride|CS-W005214
      912999-79-2

    References

    • WO2008/44041 A1, ; Page/Page column 227 ;
  • Route2
    • 5-Chloroisoindoline|CS-0443785
      127168-76-7
    • ~%
    • In-stock
      5-Chloroisoindoline hydrochloride|CS-W005214
      912999-79-2

    References

    • WO2008/44029 A1, ; Page/Page column 205 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.365
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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