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CS-W001157 4
Total: USD 88.00

4-Fluoroisoindoline hydrochloride

  • CAS No. 924305-06-6

  • Cat. No. CS-0002181
  • Purity≥96%
  • MDL No.MFCD10700143

*For research and further manufacturing use only, not for direct human use.

4-Fluoroisoindoline hydrochloride|CS-0002181

Structure of 924305-06-6

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General Information

  • CAS No. 924305-06-6
  • Cat. No. CS-0002181
  • Purity ≥96%
  • MDL No. MFCD10700143
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClFN
  • Molecular Weight 173.62
  • Synonym(s) 4-fluoroisoindoline HCL
  • SMILES FC1=CC=CC2=C1CNC2.Cl

Description

4-Fluoroisoindoline hydrochloride is a bench-stable, moisture-tolerant heterocyclic building block featuring a fluorinated aromatic core. This electron-deficient scaffold integrates readily into pharmaceutical intermediates and functional materials, offering enhanced reactivity in cross-coupling and cyclization processes under standard conditions.

Application

4-Fluoroisoindoline hydrochloride serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds prevalent in bioactive molecules. Its bench-stable form facilitates handling and purification, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound reacts readily in standard coupling and functionalization reactions, supporting efficient access to complex architectures in drug discovery workflows.

Synthesis

  • Route1
    • 2-Benzyl-4-fluoroisoindoline|CS-0670097
      685565-16-6
    • ~90%
    • In-stock
      4-Fluoroisoindoline hydrochloride|CS-0002181
      924305-06-6

    References

    • SMITHKLINE BEECHAM CORPORATION; ANACOR PHARMACEUTICALS, INC. Patent: WO2009/46098 A1, 2009 ; Location in patent: Page/Page column 68-69 ;
  • Route2
    • null|null
      1158357-58-4
    • ~95%
    • In-stock
      4-Fluoroisoindoline hydrochloride|CS-0002181
      924305-06-6

    References

    • Roche Palo Alto LLC Patent: US2009/143589 A1, 2009 ; Location in patent: Page/Page column 8 ; US 20090143589 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.8507
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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