Propargyl-C2-NHS ester

Name: Propargyl-C2-NHS ester
Brand: ChemScene
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CAS No. 906564-59-8
Cat. No. CS-0105050
Purity≥97%
MDL No.MFCD28898858

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 906564-59-8
Cat. No. CS-0105050
Purity ≥97%
MDL No. MFCD28898858
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₁NO₄
Molecular Weight 209.20
Synonym(s) None
SMILES C#CCCCC(ON1C(CCC1=O)=O)=O

Description

Propargyl-C2-NHS ester enables site-specific bioconjugation via copper-free click chemistry. The C2 spacer enhances solubility and reduces steric interference, while the NHS ester facilitates efficient coupling to primary amines under physiological conditions. This reagent delivers reliable conjugation in complex biological environments.

Application

Propargyl-C2-NHS ester serves as a versatile bioconjugation reagent, enabling efficient coupling to primary amines under mild conditions. The propargyl group provides a reliable handle for click chemistry applications, particularly with azides via CuAAC or strain-promoted cycloadditions. Its C2 spacer offers optimal distance for reactive functionality while maintaining excellent stability and ease of purification, making it well-suited for labeling peptides, proteins, and other biomolecules in synthetic and medicinal chemistry workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

TPSA 63.68
LogP 0.3971
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 4

Other Classifications

Life Science Click Chemistry Reagents

Life Science Linker Non-PEG linker

Life Science ADC Related Compound Non-cleavable linker

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

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Propargyl-C2-NHS ester

CAS No. 906564-59-8

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