Propargyl-C1-NHS ester

Name: Propargyl-C1-NHS ester
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 132178-37-1
Cat. No. CS-0105047
Purity≥95%
MDL No.MFCD22577791

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 132178-37-1

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 132178-37-1
Cat. No. CS-0105047
Purity ≥95%
MDL No. MFCD22577791
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₉NO₄
Molecular Weight 195.17
Synonym(s) None
SMILES C#CCCC(ON1C(CCC1=O)=O)=O

Description

Propargyl-C1-NHS ester enables site-specific bioconjugation via copper-free click chemistry. The reactive NHS ester facilitates efficient coupling to amine-containing biomolecules, while the terminal alkyne group supports orthogonal labeling with azide-functionalized probes. This bifunctional reagent offers high stability under standard conditions and delivers reliable conjugation in aqueous environments.

Application

Propargyl-C1-NHS ester serves as a versatile bioconjugation reagent, enabling efficient coupling to primary amines under mild aqueous conditions. The propargyl group provides a reliable handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC), facilitating site-specific labeling and conjugation in protein and oligonucleotide workflows. Its C1 spacer optimizes solubility and reduces steric hindrance, while the NHS ester offers high reactivity and stability during storage and handling.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 63.68
LogP 0.007
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 3

Other Classifications

Life Science Click Chemistry Reagents

Life Science Linker Alkyne PEG

Life Science Linker Propargyl PEG

Life Science ADC Related Compound Non-cleavable linker

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Key Words

Propargyl-C1-NHS ester sigmaPropargyl-C1-NHS ester manufacturerPropargyl-C1-NHS ester pricePropargyl-C1-NHS ester structurePropargyl-C1-NHS ester SDSbuy Propargyl-C1-NHS esterPropargyl-C1-NHS ester supplierPropargyl-C1-NHS ester usesPropargyl-C1-NHS ester molecular weightprice of Propargyl-C1-NHS esterPropargyl-C1-NHS ester chemical name formula of Propargyl-C1-NHS ester

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Propargyl-C1-NHS ester

CAS No. 132178-37-1

Recommended Products