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CS-W001157 4
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4-Fluoro-3-methoxy-N-methylaniline

  • CAS No. 904321-01-3

  • Cat. No. CS-0654869
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-3-methoxy-N-methylaniline|CS-0654869

Structure of 904321-01-3

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General Information

  • CAS No. 904321-01-3
  • Cat. No. CS-0654869
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀FNO
  • Molecular Weight 155.17
  • Synonym(s) None
  • SMILES CNC1=CC(=C(C=C1)F)OC

Description

4-Fluoro-3-methoxy-N-methylaniline features a strategically positioned fluorine atom and methoxy group that enhance electronic modulation and metabolic stability. The N-methyl substitution improves lipophilicity and membrane permeability, making this an effective building block for bioactive molecule synthesis under standard conditions.

Application

4-Fluoro-3-methoxy-N-methylaniline serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles and drug-like scaffolds. Its trifunctional profile—fluorine for metabolic stability, methoxy for electronic modulation, and N-methylamino for improved lipophilicity—facilitates direct incorporation into diverse synthetic sequences. The compound exhibits excellent bench stability, tolerates standard coupling conditions, and simplifies purification due to its distinct polarity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   1.876
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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