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CS-W001157 4
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2-Fluoro-3-methoxyaniline

  • CAS No. 801282-00-8

  • Cat. No. CS-W004858
  • Purity≥95%
  • MDL No.MFCD11042216

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-3-methoxyaniline|CS-W004858

Structure of 801282-00-8

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General Information

  • CAS No. 801282-00-8
  • Cat. No. CS-W004858
  • Purity ≥95%
  • MDL No. MFCD11042216
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FNO
  • Molecular Weight 141.14
  • Synonym(s) Benzenamine, 2-fluoro-3-methoxy-, hydrochloride
  • SMILES FC1=C(N)C=CC=C1OC

Description

2-Fluoro-3-methoxyaniline features a fluorine atom at the ortho position and a methoxy group at the meta position relative to the amine, creating a uniquely polarized aromatic scaffold. This electronic asymmetry enhances reactivity in cross-coupling processes and improves solubility in polar organic media. The molecule exhibits bench-stable handling under standard conditions and serves as a key intermediate for bioactive heterocycles and functional materials.

Application

2-Fluoro-3-methoxyaniline serves as a versatile building block for pharmaceutical intermediates and agrochemicals, enabling efficient access to substituted heterocycles via standard coupling reactions. Its ortho-fluoro and meta-methoxy substituents provide balanced electronic modulation and enhanced stability under typical synthetic conditions, facilitating direct functionalization and minimizing side reactions. The compound exhibits excellent bench stability and is amenable to purification by distillation or chromatography, making it well-suited for scalable process development.

Synthesis

  • Route1
    • Tert-butyl (2-fluoro-3-methoxyphenyl)carbamate|CS-1214104
      801281-99-2
    • ~92%
    • In-stock
      2-Fluoro-3-methoxyaniline|CS-W004858
      801282-00-8

    References

    • SUZHOU KINTOR PHARMACEUTICALS,INC.; TONG, Youzhi Patent: WO2012/119559 A1, 2012 ; Location in patent: Page/Page column 77-78 ; WO 2012/119559 A1
  • Route2

    References

    • MERCK SHARP and DOHME LIMITED Patent: WO2005/47279 A1, 2005 ; Location in patent: Page/Page column 38 ; WO 2005/047279 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.4165
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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