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Thiophene-3,4-diamine dihydrochloride

  • CAS No. 90069-81-1

  • Cat. No. CS-W015990
  • Purity≥98%
  • MDL No.MFCD00671511

*For research and further manufacturing use only, not for direct human use.

Thiophene-3,4-diamine dihydrochloride|CS-W015990

Structure of 90069-81-1

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General Information

  • CAS No. 90069-81-1
  • Cat. No. CS-W015990
  • Purity ≥98%
  • MDL No. MFCD00671511
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈Cl₂N₂S
  • Molecular Weight 187.09
  • Synonym(s) 3,4-Thiophendiamine dihydrochloride
  • SMILES NC1=CSC=C1N.Cl.Cl

Description

Thiophene-3,4-diamine dihydrochloride delivers a highly reactive, bench-stable scaffold for conjugate addition and transition-metal-catalyzed coupling. The diamine moiety, flanked by electron-rich thiophene rings, enables efficient integration into functionalized heterocycles. This form ensures enhanced solubility in polar media and simplified handling under standard conditions.

Application

Thiophene-3,4-diamine dihydrochloride serves as a versatile building block for the synthesis of functionalized heterocycles and bioactive scaffolds. Its dual amine functionality enables straightforward conjugation in amide couplings, reductive amination, and transition-metal-catalyzed cross-coupling reactions. The dihydrochloride salt form enhances solubility and bench stability, facilitating handling and purification in synthetic workflows. Widely employed in medicinal chemistry and materials science, it functions as a key intermediate for constructing thiophene-based pharmaceuticals and conductive polymers.

Synthesis

  • Route1

    References

    • Kuraray Co., Ltd.; Kondou, Yoshirou; Nakano, Kirihiro; Otake, Tomiaki Patent: US8519150 B2, 2013 ; Location in patent: Page/Page column 33 ;
  • Route2
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      19985-45-6
    • ~%
    • In-stock
      Thiophene-3,4-diamine dihydrochloride|CS-W015990
      90069-81-1

    References

    • Synthesis, , # 12 p. 1124 - 1126

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H317-H318
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.04
  • LogP   1.7561
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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