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CS-W001157 4
Total: USD 88.00

Bis(4-chlorophenyl)methanol

  • CAS No. 90-97-1

  • Cat. No. CS-W012609
  • Purity≥97%
  • MDL No.MFCD00000629

*For research and further manufacturing use only, not for direct human use.

Bis(4-chlorophenyl)methanol|CS-W012609

Structure of 90-97-1

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General Information

  • CAS No. 90-97-1
  • Cat. No. CS-W012609
  • Purity ≥97%
  • MDL No. MFCD00000629
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₀Cl₂O
  • Molecular Weight 253.12
  • Synonym(s) 4,4-Dichlorobenzhydrol
  • SMILES OC(C1=CC=C(Cl)C=C1)C2=CC=C(Cl)C=C2

Description

Bis(4-chlorophenyl)methanol features two 4-chlorophenyl groups attached to a central methanol carbon, delivering enhanced stability and solubility in polar organic solvents. This bench-stable compound serves as a key intermediate in the synthesis of functionalized diarylmethanes and pharmaceutical building blocks.

Application

Bis(4-chlorophenyl)methanol serves as a reliable building block for the synthesis of diarylmethane scaffolds, exhibiting good bench stability and ease of handling. It functions as a versatile precursor in nucleophilic substitution and coupling reactions, particularly in the construction of biaryl systems and heterocyclic frameworks. The molecule's functional group tolerance facilitates downstream modifications, making it a practical choice for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Kharul, Rajendra K.; Goswami, Amitgiri; Gite, Archana; Godha, Atul K.; Jain, Mukul; Patel, Pankaj R. Synthetic Communications, 2008 , vol. 38, # 11 p. 1703 - 1717
  • Route2

    References

    • Mori, Keiji; Sueoka, Shosaku; Akiyama, Takahiko Chemistry Letters, 2009 , vol. 38, # 6 p. 628 - 629
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 60, # 8 p. 2430 - 2435

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   4.0751
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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