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6-Bromo-8-methyl-[1,2,4]triazolo[1,5-a]pyridine

  • CAS No. 899429-04-0

  • Cat. No. CS-0147292
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-8-methyl-[1,2,4]triazolo[1,5-a]pyridine|CS-0147292

Structure of 899429-04-0

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General Information

  • CAS No. 899429-04-0
  • Cat. No. CS-0147292
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrN₃
  • Molecular Weight 212.05
  • Synonym(s) 6-Bromo-8-methyl[1,2,4]triazolo[1,5-a]pyridine
  • SMILES CC1=CC(Br)=CN2C1=NC=N2

Description

6-Bromo-8-methyl-[1,2,4]triazolo[1,5-a]pyridine is a heterocyclic scaffold featuring a brominated triazolopyridine core with a methyl substituent at the 8-position. This configuration enhances electronic modulation and provides a reactive handle for cross-coupling applications in medicinal chemistry and materials synthesis.

Application

6-Bromo-8-methyl-[1,2,4]triazolo[1,5-a]pyridine serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. The bromo group enables palladium-catalyzed cross-coupling reactions, while the methyl substituent enhances solubility and metabolic stability. This scaffold exhibits bench stability and compatibility with diverse functional groups, facilitating efficient synthesis of complex polycyclic architectures.

Synthesis

  • Route1
    • N'-(5-Bromo-3-methylpyridin-2-yl)-N,N-dimethylmethanimidamide|CS-0204917
      883052-76-4
    • ~%
    • In-stock
      6-Bromo-8-methyl-[1,2,4]triazolo[1,5-a]pyridine|CS-0147292
      899429-04-0

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3614 - 3627
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3614 - 3627

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   1.80022
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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