2,4-Dichloro-6-(propan-2-yl)pyrimidine

Name: 2,4-Dichloro-6-(propan-2-yl)pyrimidine
Brand: ChemScene
Availability: InStock
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CAS No. 89938-05-6
Cat. No. CS-0057836
Purity≥98%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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2,4-Dichloro-6-(propan-2-yl)pyrimidine|CS-0057836

Structure of 89938-05-6

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General Information

CAS No. 89938-05-6
Cat. No. CS-0057836
Purity ≥98%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈Cl₂N₂
Molecular Weight 191.06
Synonym(s) 2,4-Dichloro-6-isopropylpyrimidine
SMILES CC(C)C1=CC(=NC(=N1)Cl)Cl

Description

This pyrimidine derivative features a sterically hindered isopropyl group at the 6-position, enhancing stability and solubility in organic media. The electron-withdrawing dichloro substituents at the 2- and 4-positions create a strongly electron-deficient heterocycle ideal for cross-coupling reactions. This compound serves as a key scaffold in medicinal chemistry for kinase inhibitor development and functionalized heterocycle synthesis under standard conditions.

Application

2,4-Dichloro-6-(propan-2-yl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its dual chloro substituents facilitate nucleophilic substitution reactions under mild conditions, while the isopropyl group enhances solubility and metabolic stability. This compound functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive heterocycles, offering reliable bench stability and straightforward purification.

Synthesis

Route1
- 58289-27-3
- ~97%
- In-stock
  
  89938-05-6
References
- MITSUBISHI TANABE PHARMA CORPORATION; MORIMOTO, Hiroshi; SAKAMOTO, Toshiaki; HIMIYAMA, Toshiyuki; KAWANISHI, Eiji; MATSUMURA, Takehiko Patent: WO2010/30027 A1, 2010 ; Location in patent: Page/Page column 56-57 ; WO 2010/030027 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 2.9068
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2,4-Dichloro-6-(propan-2-yl)pyrimidine

CAS No. 89938-05-6

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