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CS-W001157 4
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1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid

  • CAS No. 898746-35-5

  • Cat. No. CS-0044128
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid|CS-0044128

Structure of 898746-35-5

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General Information

  • CAS No. 898746-35-5
  • Cat. No. CS-0044128
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O₂
  • Molecular Weight 162.15
  • Synonym(s) 1H-Pyrrolo[2,3-b]pyridine-6-carboxylicacid
  • SMILES O=C(C1=CC=C2C(NC=C2)=N1)O

Description

1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid is a heteroaromatic scaffold featuring a carboxylic acid group at the 6-position, enabling direct conjugation or derivatization. The fused pyrrole-pyridine core imparts enhanced planarity and electron-rich character, supporting applications in medicinal chemistry and materials science. This compound exhibits favorable solubility in polar solvents and stability under standard bench conditions.

Application

1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its carboxylic acid functionality enables direct amidation, esterification, or coupling reactions, while the fused pyrrolopyridine core provides structural rigidity and π-conjugation. The compound exhibits good bench stability and facilitates efficient synthesis of bioactive scaffolds, particularly in kinase inhibitors and fluorescent probes.

Synthesis

  • Route1

    References

    • WO2012/95463 A1, ; Page/Page column 80 ;
  • Route2

    References

    • WO2012/95463 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.2611
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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