4-Chloro-2-cyclopropylquinazoline

Name: 4-Chloro-2-cyclopropylquinazoline
Brand: ChemScene
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CAS No. 898044-61-6
Cat. No. CS-0433079
Molecule weight204.66
Purity≥98%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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4-Chloro-2-cyclopropylquinazoline|CS-0433079

Structure of 898044-61-6

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General Information

CAS No. 898044-61-6
Cat. No. CS-0433079
Purity ≥98%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₉ClN₂
Molecular Weight 204.66
Synonym(s) None
SMILES ClC1=C2C=CC=CC2=NC(C3CC3)=N1

Description

4-Chloro-2-cyclopropylquinazoline is a sterically constrained quinazoline derivative featuring a chloro substituent at the 4-position and a cyclopropyl group at the 2-position. This combination imparts enhanced metabolic stability and favorable lipophilicity, enabling efficient integration into kinase inhibitor scaffolds. The molecule demonstrates robust bench stability under standard conditions, facilitating straightforward handling in medicinal chemistry workflows.

Application

4-Chloro-2-cyclopropylquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinazoline-based scaffolds. The chloro group at the 4-position facilitates nucleophilic substitution reactions, while the cyclopropyl moiety at the 2-position provides steric and electronic modulation. This compound exhibits excellent bench stability and compatibility with standard coupling protocols, facilitating rapid diversification in target-oriented synthesis.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 3.1606
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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4-Chloro-2-cyclopropylquinazoline

CAS No. 898044-61-6

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