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CS-W001157 4
Total: USD 88.00

4-Chloro-5-fluoro-6-methylpyrimidine

  • CAS No. 898044-55-8

  • Cat. No. CS-W018883
  • Molecule weight146.55
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Chloro-5-fluoro-6-methylpyrimidine|CS-W018883

Structure of 898044-55-8

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General Information

  • CAS No. 898044-55-8
  • Cat. No. CS-W018883
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄ClFN₂
  • Molecular Weight 146.55
  • Synonym(s) None
  • SMILES CC1=NC=NC(Cl)=C1F

Description

4-Chloro-5-fluoro-6-methylpyrimidine is a halogenated pyrimidine scaffold featuring complementary electron-withdrawing fluorine and chlorine substituents, enabling selective functionalization in medicinal chemistry. The methyl group enhances lipophilicity and metabolic stability, making this heterocycle valuable for constructing bioactive compounds.

Application

4-Chloro-5-fluoro-6-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyrimidine scaffolds through palladium-catalyzed cross-coupling reactions. Its orthogonal reactivity profile—combining electrophilic halogen sites with a methyl group for further functionalization—facilitates modular synthesis of bioactive molecules. The compound exhibits excellent bench stability and compatibility with common reaction conditions, simplifying purification and scale-up in API development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.57752
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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