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CS-W001157 4
Total: USD 88.00

(2-Chloro-5-methoxyphenyl)boronic acid

  • CAS No. 89694-46-2

  • Cat. No. CS-M1978
  • Purity≥96%
  • MDL No.MFCD06659858

*For research and further manufacturing use only, not for direct human use.

(2-Chloro-5-methoxyphenyl)boronic acid|CS-M1978

Structure of 89694-46-2

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General Information

  • CAS No. 89694-46-2
  • Cat. No. CS-M1978
  • Purity ≥96%
  • MDL No. MFCD06659858
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BClO₃
  • Molecular Weight 186.40
  • Synonym(s) 2-Chloro-5-methoxyphenylboronic acid
  • SMILES ClC1=CC=C(OC)C=C1B(O)O

Description

This boronic acid features a chlorine and methoxy group positioned ortho and para to the boronate moiety, enabling selective coupling in Suzuki-Miyaura reactions. The electron-withdrawing chlorine enhances reactivity, while the methoxy substituent improves solubility and stability under standard conditions.

Application

(2-Chloro-5-methoxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. Its stability, ease of handling, and compatibility with diverse functional groups make it well-suited for the synthesis of substituted biaryls and complex heterocycles. The chloro and methoxy substituents provide orthogonal reactivity and electronic tuning, enhancing its utility in medicinal chemistry and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   0.0284
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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