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CS-W001157 4
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6,8-Difluoro-3,4-dihydro-2H-naphthalen-1-one

  • CAS No. 895534-38-0

  • Cat. No. CS-0036952
  • Purity≥95%
  • MDL No.MFCD11518781

*For research and further manufacturing use only, not for direct human use.

6,8-Difluoro-3,4-dihydro-2H-naphthalen-1-one|CS-0036952

Structure of 895534-38-0

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General Information

  • CAS No. 895534-38-0
  • Cat. No. CS-0036952
  • Purity ≥95%
  • MDL No. MFCD11518781
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈F₂O
  • Molecular Weight None
  • Synonym(s) 6,8-difluorotetralin-1-one
  • SMILES C1CC2=CC(=CC(=C2C(=O)C1)F)F

Description

6,8-Difluoro-3,4-dihydro-2H-naphthalen-1-one features a fluorinated naphthalenone core with enhanced electron-withdrawing character due to the ortho-fluorine substituents. This structure imparts improved metabolic stability and modulates electronic properties for use in bioactive molecule design. The compound serves as a key scaffold in medicinal chemistry, particularly for kinase inhibitors and CNS-targeted therapeutics.

Application

6,8-Difluoro-3,4-dihydro-2H-naphthalen-1-one serves as a versatile fluorinated building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-deficient aromatic core enables efficient Suzuki-Miyaura and Buchwald-Hartwig couplings, while the difluoro substitution enhances metabolic stability and modulates lipophilicity. Bench-stable and readily purified by flash chromatography, it functions effectively in multi-step syntheses requiring ortho-functionalized naphthalene scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.4838
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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