Lot numbers can be found on the outside label of a product:
6-fluoro-1,2,3,4-tetrahydronaphthalen-1-one
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CAS No. 703-67-3
- Cat. No. CS-W004321
- Purity≥95%
- MDL No.MFCD09031370
*For research and further manufacturing use only, not for direct human use.
Structure of 703-67-3
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General Information
- CAS No. 703-67-3
- Cat. No. CS-W004321
- Purity ≥95%
- MDL No. MFCD09031370
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₉FO
- Molecular Weight 164.18
- Synonym(s) 6-fluoro-3,4-dihydronaphthalen-1(2H)-one
- SMILES Fc1ccc2c(c1)CCCC2=O
Description
6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-one features a fluorinated tetralin core with a ketone functionality at the 1-position, offering enhanced electronic and steric properties. This scaffold integrates readily into medicinal chemistry libraries, serving as a key building block for bioactive molecules requiring lipophilic character and metabolic stability.
Application
6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-one serves as a valuable building block in medicinal chemistry, enabling access to fluorinated tricyclic scaffolds. Its ketone functionality facilitates nucleophilic additions and reductive transformations, while the fluoro substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with standard synthetic protocols, supporting its use in multi-step syntheses of bioactive molecules.
Synthesis
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Route1
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In-stock
70631-88-8 - ~99%
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In-stock
703-67-3
References
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ELI LILLY AND COMPANY Patent: WO2005/92854 A1, 2005 ; Location in patent: Page/Page column 2 ; WO 2005/092854 A1
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Route2
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69797-47-3 - ~53%
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In-stock
703-67-3
References
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F. HOFFMANN-LA ROCHE AG Patent: WO2006/66748 A1, 2006 ; Location in patent: Page/Page column 23; 24 ; WO 2006/066748 A1
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Route3
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In-stock
3470-50-6 - ~%
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In-stock
703-67-3
References
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Organic Letters, , vol. 13, # 24 p. 6488 - 6491
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 17.07
- LogP 2.3447
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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