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CS-W001157 4
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(6-Methoxypyridazin-3-yl)methanol

  • CAS No. 89532-79-6

  • Cat. No. CS-0056607
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(6-Methoxypyridazin-3-yl)methanol|CS-0056607

Structure of 89532-79-6

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General Information

  • CAS No. 89532-79-6
  • Cat. No. CS-0056607
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O₂
  • Molecular Weight 140.14
  • Synonym(s) 6-methoxy-3-Pyridazinemethanol
  • SMILES COC1=NN=C(C=C1)CO

Description

(6-Methoxypyridazin-3-yl)methanol features a pyridazine core functionalized with a methoxy group at the 6-position and a primary alcohol at the 3-position. This combination imparts enhanced solubility and metabolic stability, enabling direct incorporation into bioactive scaffolds. The pendant hydroxymethyl moiety facilitates further derivatization via esterification or ether formation, streamlining access to diverse compound libraries in medicinal chemistry.

Application

(6-Methoxypyridazin-3-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridazinyl-containing scaffolds. Its benzylic alcohol functionality facilitates derivatization via oxidation, etherification, or esterification, while the 6-methoxy group enhances solubility and modulates electronic properties. The molecule exhibits good bench stability and compatibility with standard coupling reactions, making it suitable for use in parallel synthesis and fragment-based drug discovery campaigns.

Synthesis

  • Route1

    References

    • Arrington, Kenneth L.; Burgey, Christopher; Gilfillan, Robert; Han, Yongxin; Patel, Mehul; Li, Chun Sing; Li, Yaozong; Luo, Yunfu; Lei, Zhiyu Patent: US2014/100231 A1, 2014 ; Location in patent: Page/Page column ;
  • Route2

    References

    • Arrington, Kenneth L.; Burgey, Christopher; Gilfillan, Robert; Han, Yongxin; Patel, Mehul; Li, Chun Sing; Li, Yaozong; Luo, Yunfu; Lei, Zhiyu Patent: US2014/100231 A1, 2014 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.24
  • LogP   -0.0225
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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