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CS-W001157 4
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6-Methoxypyridazine-3-carboxylic acid

  • CAS No. 56434-28-7

  • Cat. No. CS-0050177
  • Molecule weight154.12
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Methoxypyridazine-3-carboxylic acid|CS-0050177

Structure of 56434-28-7

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General Information

  • CAS No. 56434-28-7
  • Cat. No. CS-0050177
  • Purity ≥96%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₃
  • Molecular Weight 154.12
  • Synonym(s) 3-pyridazinecarboxylic acid, 6-methoxy-
  • SMILES COC1=NN=C(C=C1)C(O)=O

Description

6-Methoxypyridazine-3-carboxylic acid features a pyridazine core functionalized with methoxy and carboxylic acid groups at the 6- and 3-positions, respectively. This arrangement imparts enhanced solubility and metabolic stability, enabling its use in medicinal chemistry scaffolds. The electron-deficient heterocycle facilitates coupling reactions under mild conditions, while the carboxylic acid serves as a versatile handle for derivatization.

Application

6-Methoxypyridazine-3-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyridazine-based scaffolds relevant in medicinal chemistry. Its dual functionality—electron-withdrawing carboxylic acid and methoxy substituent—facilitates diverse transformations including amidation, esterification, and coupling reactions. The compound exhibits good bench stability and moderate solubility, supporting straightforward purification and integration into standard synthetic workflows.

Synthesis

  • Route1

    References

    • ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC. Patent: WO2004/14881 A2, 2004 ; Location in patent: Page 149 ; WO 2004/014881 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   72.31
  • LogP   0.1834
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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