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CS-W001157 4
Total: USD 88.00

5-Cyclopropylpyridine-3-carboxylic acid

  • CAS No. 893738-23-3

  • Cat. No. CS-0224976
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Cyclopropylpyridine-3-carboxylic acid|CS-0224976

Structure of 893738-23-3

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General Information

  • CAS No. 893738-23-3
  • Cat. No. CS-0224976
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NO₂
  • Molecular Weight 163.17
  • Synonym(s) 5-Cyclopropylnicotinic acid
  • SMILES C1CC1C2=CC(=CN=C2)C(=O)O

Description

5-Cyclopropylpyridine-3-carboxylic acid features a cyclopropyl group at the 5-position of a pyridine ring, enhancing lipophilicity and metabolic stability. The carboxylic acid moiety enables direct conjugation or salt formation, facilitating solubility control. This scaffold integrates readily into bioactive molecules, particularly in kinase inhibitors and CNS-targeted pharmaceuticals, where its rigid, electron-deficient core supports target binding.

Application

5-Cyclopropylpyridine-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its pyridine core provides favorable electronic properties for target binding, while the cyclopropyl group enhances metabolic stability and modulates lipophilicity. The carboxylic acid functionality facilitates direct coupling reactions or derivatization, offering broad utility in peptide conjugation, prodrug design, and transition metal-catalyzed transformations. Bench-stable and readily purified by recrystallization, it functions effectively in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.6572
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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