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CS-W001157 4
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5-Chloro-[1,2,4]triazolo[1,5-a]pyrimidine

  • CAS No. 89364-06-7

  • Cat. No. CS-0343348
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Chloro-[1,2,4]triazolo[1,5-a]pyrimidine|CS-0343348

Structure of 89364-06-7

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General Information

  • CAS No. 89364-06-7
  • Cat. No. CS-0343348
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₄
  • Molecular Weight 154.56
  • Synonym(s) 5-Chloro[1,2,4]triazolo[1,5-a]pyrimidine
  • SMILES ClC1=NC2=NC=NN2C=C1

Description

5-Chloro-[1,2,4]triazolo[1,5-a]pyrimidine is a heterocyclic scaffold featuring a chlorine substituent at the 5-position, enhancing electrophilicity for nucleophilic substitution. This electron-deficient core integrates readily into pharmaceutical intermediates and bioactive molecules, offering high stability under standard reaction conditions and compatibility with diverse coupling chemistries.

Application

5-Chloro-[1,2,4]triazolo[1,5-a]pyrimidine serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its chloro substituent enables direct nucleophilic substitution, facilitating the installation of diverse side chains via C–N or C–C bond formation. The scaffold exhibits excellent bench stability and functional group tolerance, enabling straightforward incorporation into complex molecular architectures. This compound functions as a key intermediate in the synthesis of bioactive triazolopyrimidines and is well-suited for high-throughput screening campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.08
  • LogP   0.7777
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   0

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