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CS-W001157 4
Total: USD 88.00

3-Chloro-5-methylpyridazine

  • CAS No. 89283-31-8

  • Cat. No. CS-0051407
  • Purity≥97%
  • MDL No.MFCD09743645

*For research and further manufacturing use only, not for direct human use.

3-Chloro-5-methylpyridazine|CS-0051407

Structure of 89283-31-8

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General Information

  • CAS No. 89283-31-8
  • Cat. No. CS-0051407
  • Purity ≥97%
  • MDL No. MFCD09743645
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅ClN₂
  • Molecular Weight None
  • Synonym(s) 3-Chloro-5-methylpyridazine hydrochloride
  • SMILES CC1=CN=NC(Cl)=C1

Description

3-Chloro-5-methylpyridazine is a heterocyclic building block featuring a chlorinated pyridazine core with a methyl group at the 5-position. This electron-deficient scaffold integrates readily into medicinal chemistry campaigns, offering enhanced metabolic stability and tunable reactivity in cross-coupling transformations. The pendant chlorine enables direct functionalization under palladium-catalyzed conditions, while the methyl substituent modulates lipophilicity and steric profile.

Application

3-Chloro-5-methylpyridazine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. The chloropyridazine core exhibits excellent bench stability and tolerates a range of functional groups, facilitating downstream derivatization. Its reactivity profile supports reliable incorporation into bioactive molecules, particularly in the development of kinase inhibitors and targeted therapeutics.

Synthesis

  • Route1

    References

    • Helvetica Chimica Acta, , vol. 37, p. 1467,1470 Pharmaceutical Bulletin, , vol. 5, p. 229,233
  • Route2
    • 5-Methyl-3-oxo-2,3-dihydropyridazine-4-carboxylic acid|CS-0675087
      342402-51-1
    • ~%
    • In-stock
      3-Chloro-5-methylpyridazine|CS-0051407
      89283-31-8

    References

    • Helvetica Chimica Acta, , vol. 37, p. 1467,1470
  • Route3

    References

    • Pharmaceutical Bulletin, , vol. 5, p. 229,233

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07,GHS08
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335-H351
Precautionary Statements : P201-P202-P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.43842
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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