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1,3-Dimethyl-1H-pyrazole-5-carbohydrazide

  • CAS No. 89187-40-6

  • Cat. No. CS-0187755
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,3-Dimethyl-1H-pyrazole-5-carbohydrazide|CS-0187755

Structure of 89187-40-6

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General Information

  • CAS No. 89187-40-6
  • Cat. No. CS-0187755
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀N₄O
  • Molecular Weight 154.17
  • Synonym(s) 1,3-DIMETHYLPYRAZOLE-5-CARBOHYDRAZIDE
  • SMILES CC1=NN(C)C(=C1)C(=O)NN

Description

1,3-Dimethyl-1H-pyrazole-5-carbohydrazide features a pyrazole core with methyl and carbohydrazide substituents, enabling direct integration into heterocyclic scaffolds. The hydrazide group facilitates coupling reactions under mild conditions, while the electron-rich pyrazole ring enhances stability and reactivity in synthetic transformations. This compound serves as a key intermediate for bioactive molecule synthesis.

Application

1,3-Dimethyl-1H-pyrazole-5-carbohydrazide serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyrazole-based scaffolds through condensation and cyclization reactions. Its hydrazide functionality facilitates coupling with carbonyl compounds, while the methylated pyrazole core provides enhanced stability and solubility. Ideal for medicinal chemistry campaigns and API intermediate development, it offers predictable reactivity and straightforward purification, making it well-suited for high-throughput and scale-up applications.

Synthesis

  • Route1

    References

    • Tihanyi; Feher; Gal; et al. European Journal of Medicinal Chemistry, 1984 , vol. 19, # 5 p. 433 - 439

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   72.94
  • LogP   -0.66798
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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